November 22, 2013 / Analysis of pharmaceutical tablets by Raman spectroscopy

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November 22, 2013 / Analysis of pharmaceutical tablets by Raman spectroscopy

Analysis of pharmaceutical tablets by Raman spectroscopy

 

3D Scanning Laser Raman Confocal Microscope

Interdisciplinary Research at the sub-micrometer range

  • Confocal Raman / fluorescence microscopy
  • Compact modular system
  • Wide spectral range (UV,VIS, IR)
  • High sensitivity
  • High temporal and thermal stability

 

Raman confocal microscopy is widely used in pharmaceutics. Such technique allows identify chemical compounds and molecular conformers in various drugs. Measuring the distribution of the ingredients in the tablet is important for monitoring the manufacturing process and impurity testing.

In this application note Confotec MR520 instrument is used for study of the pharmaceutical tablet containing two active components - Aspirin and Paracetamol, to demonstrate capabilities of Raman technique. These active ingredients should be combined uniformly to produce a quality tablet. Homogeneous distribution of components will improve compression characteristics of tablets, their hardness and lifetime.

The tablet exhibits two characteristic types of Raman spectra (Fig. 1). Spectra in Fig.1 correspond to two main components of tablet: Aspirin and Paracetamol. Raman spectrum of Paracetamol consists characteristic bands at 1650 cm-1 (C=O) and 1612 cm-1 (N-H). Raman spectrum of aspirin has the characteristic bands at 1606 (C-C) and 1622 cm-1 (C-O stretching vibrations of the carboxyl group).

 

Characteristic Raman spectra of Aspirin and Paracetamol used to map distribution of chemical compounds in the tablet (Fig.2)

It is possible to see homogeneous distribution of active components within the investigated tablet (Fig.2)

Conclusion

Raman confocal microscopy is a powerful tool for pharmaceutical applications. Distribution of Aspirin and Paracetamol components within the tablet has been studied with the high spatial resolution.

 

 

 SOL instruments: спектрометр, рамановский микроскоп, эмиссионный спектрометр. confotec mr520 sait 800

Figure 1

SOL instruments: спектрометр, рамановский микроскоп, эмиссионный спектрометр. pharma tablet fig1

Raman spectra of Aspirin (green color) and Paracetamol (red color)

Figure 2

SOL instruments: спектрометр, рамановский микроскоп, эмиссионный спектрометр. pharma tablet fig2
Distribution of chemical compounds in the tablet.
Green color corresponds to Aspirin.
Red color corresponds to Paracetamol.